Loss of Epas1 promotes FSGS

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EPAS1 promotes adipose differentiation in 3T3-L1 cells.

Adipose differentiation is regulated by several transcription factors, such as the CAAT/enhancer-binding protein family and peroxisome proliferator activator (PPAR) gamma2. Several recent studies have shown that the basic helix-loop-helix-PAS superfamily is also involved in the regulation of adipose differentiation. In this study, we investigated the roles played by EPAS1 (endothelial PAS domai...

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ژورنال

عنوان ژورنال: Nature Reviews Nephrology

سال: 2017

ISSN: 1759-5061,1759-507X

DOI: 10.1038/nrneph.2017.143